Acculturation Predicts Negative Affect and Shortened Telomere Length

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Association between shortened leukocyte telomere length and cardio-metabolic outcomes.

In their meta-analysis of 27 published studies, D’Mello et al show that shortened leukocyte telomere length (LTL) is associated with 3 primary end points: myocardial infarction, stroke, and type 2 diabetes mellitus. The meta-analysis and its findings raise several fundamental issues that are worth considering. After discussing the major findings and limitations, we focus on 3 central themes: th...

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Telomere length in early life predicts lifespan.

The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an important role in cell deterioration with advancing age. The observed variation in telomere length among individuals of the same age is therefore thought to be related to variation in potential longevity. Studies of this relationship are hampered by the time scale over which individuals need to be followed, par...

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Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.

BACKGROUND Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its associ...

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ژورنال

عنوان ژورنال: Biological Research For Nursing

سال: 2016

ISSN: 1099-8004,1552-4175

DOI: 10.1177/1099800416672005